AB0312 INCREASED PREVALENCE OF OBSTRUCTIVE SLEEP APNEA IN INDIVIDUALS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Background: Sleep disturbances are common in individuals with rheumatological diseases general and systemic lupus erythematosus (SLE) particular 1 . Studies suggest that obstructive sleep apnea (OSA) might correlate SLE disease activity the presence of additional symptoms such as pain, fatigue, affective steroid use 2 symptomatology fatigue increased pain overlap constitutional inflammatory may mimic or mask related relapse 3,4 Therein lies importance diagnosing treating disorders SLE. Objectives: To determine whether patients have prevalence OSA assessed by hypopnea index (AHI) to explore possible contributors including accrued damage, medications, secondary fibromyalgia depression. Methods: 42 consecutive (38 women, 4 men) 20 healthy, sex, body mass (BMI) age matched controls (15 5 were consecutively recruited underwent an ambulatory study using WatchPAT device. All participants completed questionnaires Pittsburgh Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Functional Assessment Chronic Illness Therapy (FACIT), Widespread Pain (WPI), Symptoms Severity (SSS) Beck Depression Inventory. damage Systemic Lupus Erythematosus Disease Activity (SLEDAI) International Collaborating Clinics (SLICC) index. Results: The mean AHI was 9.19 ± 6.79 group 3.95 3.47 control (p=0.004). Moderate-severe (AHI≥15) significantly more (23.6% vs. 0%, p=0.04). Patients had lower efficiency (83.38 6.15 87.22 4.24, p=0.03), arousals (7.72 5.66 5.13 2.29, p=0.01), higher PSQI FACIT scores (8.14 5.10 2.64, p=0.001, 16.89 11.19 7.29 5.93, p= 0.0008 respectively) WPI SSS (19.5% BMI SLICC score independent predictors (p=0.03 p=0.02 respectively). A correlation between SLEDAI moderate-severe found (p=0.03), although association depression not found. Conclusion: quality compared healthy controls. Our findings a OSA. References: [1]Wu, L., Shi, P. Tao, S. S., J. H. & Wu, G. C. Decreased erythematosus: meta-analysis. Clin. Rheumatol. (2020) doi:10.1007/s10067-020-05300-3. [2]Palagini, L. et al. erythematosus. vol. 23 115–123 (2014). [3]Javaheri, Javaheri, Update on Persistent Excessive Daytime Chest 158 776–786 (2020). [4]Mertz, Towards practical management Science Medicine 7 Table 1. parameters analysis n = Control P value RDI SD 13.52 6.54 9.72 3.60 0.04 0.004 ODI 2.54 2.72 1.27 1.45 (%) 83.38 4.24 0.03 Number 7.72 2.29 0.01 Saturation 96.10 1.37 95.75 1.39 0.45 latency 21.25 9.33 18.46 6.63 0.27 REM 87.88 49.06 73.60 46.21 0.09 25.35 14.03 27.32 0.15 Light 57.63 12.37 52.70 11.63 0.18 Deep 17.89 5.59 18.76 6.70 0.54 SLE, Erythematosus; RDI, Respiratory Disturbance Index; SD, Standard Deviation; AHI, Apnea Hypopnea ODI, Oxygen Desaturation Rapid Eye Movement. Disclosure Interests: None declared